Sunitinib-Induced Acute Interstitial Nephritis in a Thrombocytopenic Renal Cell Cancer Patient

Figure 1

Renal biopsy demonstrating acute interstitial nephritis (H&E staining): there is edema and an extensive dense interstitial chronic inflammatory infiltrate in the cortex and medulla. (a) In the lower power photomicrograph (left, 100x), the renal cortex shows extensive interstitial chronic inflammation with occasional lymphocytic tubulitis (arrow). In areas of inflammation, there is evidence of acute tubular injury with proximal tubules demonstrating lumenal distension with epithelial flattening. There was no evidence of glomerulitis, vasculitis, or thrombotic microangiopathy. (b) The higher magnification photomicrograph (right, 600x) shows that the interstitial inflammatory cells comprised frequent eosinophils (arrows) as well as lymphocytes and fewer plasma cells.

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