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Case Reports in Oncological Medicine
Volume 2017, Article ID 7072615, 4 pages
Case Report

All That Wheezes Is Not Asthma: A Case of Diffuse Large B-Cell Lymphoma of the Larynx

1University of Arizona College of Medicine, Tucson, AZ, USA
2Department of Medicine, University of Arizona, Tucson, AZ, USA
3Department of Hematology & Oncology, University of Arizona, Tucson, AZ, USA

Correspondence should be addressed to Bushra Rahman; ude.anozira.liame@namharb

Received 5 November 2016; Revised 1 March 2017; Accepted 2 March 2017; Published 15 March 2017

Academic Editor: Jose I. Mayordomo

Copyright © 2017 Bushra Rahman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Localized laryngeal lymphoma is a rare entity with an incidence of less than 1% of all laryngeal neoplasms. Diffuse large B-cell lymphoma (DLBCL) is the most common type of laryngeal neoplasms. Here, we describe a case of a young 28-year-old female with large B-cell lymphoma who remained undiagnosed for a long time owing to a myriad of nonspecific presentation including “wheezing.” Although primary laryngeal lymphomas constitute a diagnostic challenge since they are rare, one should have a high index of suspicion for lymphoma of the larynx in patients presenting with unresolved wheezing as it can present catastrophically with acute airway obstruction requiring immediate surgical intervention which was observed in this case. Treatment includes radiotherapy, chemotherapy, immunotherapy, or a combination of these. We hope that the discussions ensuing from case reports regarding uncommon presentations of laryngeal lymphoma may spur the formation of regional/international databases for the description of lymphomas with unusual presentations. This effort can lead to in-depth study of cases and prompt awareness of “rare and subtle presentations” of laryngeal lymphoma.