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Case Reports in Oncological Medicine
Volume 2017, Article ID 8120689, 3 pages
Case Report

Anti-Yo Mediated Paraneoplastic Cerebellar Degeneration Associated with Pseudobulbar Affect in a Patient with Breast Cancer

1Department of Surgery, University of Virginia, Charlottesville, VA, USA
2Department of Medicine, University of Virginia, Charlottesville, VA, USA
3Department of Neurology, University of Virginia, Charlottesville, VA, USA

Correspondence should be addressed to Patrick M. Dillon; ude.ainigriv.ccm.liamcsh@b5dmp

Received 6 January 2017; Accepted 23 February 2017; Published 9 March 2017

Academic Editor: Katsuhiro Tanaka

Copyright © 2017 Allison N. Martin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Paraneoplastic cerebellar degeneration (PCD) is a rare anti-Yo mediated paraneoplastic syndromes rarely that is infrequently associated with breast cancer. We present a case of a 52-year-old female presenting with diplopia, gait instability, dysarthria, dysphagia, nystagmus, and, most notably, new onset paroxysmal episodes of uncontrollable crying concerning for pseudobulbar affect (PBA). Serologic testing showed anti-Yo antibodies. The patient was found to have stage IIIA breast cancer as the inciting cause of the paraneoplastic syndrome. The patient was treated with neoadjuvant chemotherapy, modified radical mastectomy, adjuvant Herceptin, and pertuzumab. She was given IVIG for paraneoplastic syndrome, antidepressants, and dextromethorphan-quinidine (Nuedexta), the first FDA-approved therapy for PBA. With multimodality therapy, she demonstrated significant improvement in neurologic and mood symptoms associated with PCD and PBA.