Acquired von Willebrand Disease Associated with Monoclonal Gammopathy of Unknown Significance

Table 1

Lab tests done during presentation, treatment, and a month after treatment.

Lab test	Presentation	During treatment (3 days)	1 month after treatment	Reference range
INR	1.1	N/A	1.1	0.9–1.1
PTT (sec)	48	N/A	34.9	23–34 s
Factor VIII activity (%)	12	33	114	50–160%
Factor IX activity (%)	166	N/A	N/A	60–150%
Factor XI activity	98	N/A	N/A	50–150%
Factor XII activity	54	N/A	N/A	50–150%
vWF antigen (%)	6	10	95	60–150%
Ristocetin cofactor assay (%)	< 20	< 20	81	50–160%
vWF multimer analysis	Normal	N/A	N/A	Normal multimeric distribution
Bethesda assay	0	N/A	N/A	0

INR: international normalized ratio; PTT: partial thromboplastin time; vWF: von Willebrand factor; N/A: not available.