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Case Reports in Oncological Medicine
Volume 2018, Article ID 3512847, 6 pages
https://doi.org/10.1155/2018/3512847
Case Report

Case Reports in Oncological Medicine Myoepithelioma: A New Rearrangement Involving the LPP Locus in a Case of Multiple Bone and Soft Tissue Lesions

1Department of Pathology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
2Center for Human Genetics, Cliniques Universitaires Saint-Luc–Université catholique de Louvain, Brussels, Belgium
3Department of Pathology, Katholieke Universiteit Leuven, Leuven, Belgium
4Department of Orthopaedic Surgery, Cliniques Universitaires Saint-Luc, Brussels, Belgium
5Department of Medical Imaging, Cliniques Universitaires St-Luc, Brussels, Belgium
6Center for Human Genetics, Cliniques Universitaires Saint-Luc and Human Molecular Genetics, de Duve Institute, Université catholique de Louvain, Brussels, Belgium
7Department of Pathology, Cliniques Universitaires St-Luc and IREC, Pôle de morphologie MORF, Université Catholique de Louvain, Brussels, Belgium

Correspondence should be addressed to Hélène A. Poirel; moc.xmg@leriop-eniotna.eneleh

Hélène A. Poirel and Christine Galant contributed equally to this work.

Received 5 October 2017; Accepted 10 December 2017; Published 27 February 2018

Academic Editor: Giovann Tallini

Copyright © 2018 Géraldine Pairet et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We report a case of multiple myoepithelioma with synchronous bone and soft tissue tumors, associated with a new genomic alteration of the LPP locus. The lesions occurred in the foot by presenting one lump in the plantar soft tissue, and three lesions were detected in the calcaneus and in the navicular bone. All tumors showed the double immunophenotype of epithelial markers and S100 protein expression. No rearrangement of the EWSR1 and FUS loci was detected as reported in myoepitheliomas. However, molecular karyotyping detected an unbalanced rearrangement of the LPP locus, not involving the HMGA2 locus, which is the most frequent translocation partner observed in benign mesenchymal tumors such as lipomas (of soft tissue as well as parosteal) and pulmonary chondroid hamartoma.