Leiomyosarcoma of the Rectum as a Radiation-Induced Second Malignancy after Cervical Cancer Treatment: Case Report with Review of the Literature

Table 1

Pooled data of all identified case reports of radiation-induced leiomyosarcoma of the rectum after pelvic radiation therapy for cervical cancer.

Authors	Year of publication	Patient’s age at diagnosis	Overall irradiation dosage (Gy)	Radiation modality	Time to diagnosis of a secondary malignancy (years)	Selected treatment strategy
Drumea et al. [11]	1993	62	70	40 Gy; EBRT^1+30 Gy BT^2	17	Intra-abdominal resection of the rectum
Caporale et al. [12]	2003	N/A	N/A	N/A	N/A	N/A
Basu et al. [13]	2012	79	N/A	N/A	26	Intra-abdominal resection of the rectum
Garcia-Ortega et al. [14]	2018	58	85	50 Gy; EBRT+35 Gy BT	8	Sigmostomy+chemotherapy+pelvic exenteration+vulvectomy
Jayakumar et al. [15]	2015	58	N/A	N/A	15	Local excision
Current case report	2019	62	100.5	70 Gy EBRT+30.5 Gy BT	32	ТМЕ+CME/CVL

¹EBRT: external beam radiation therapy. ²BT: brachytherapy.