Case Report
Leiomyosarcoma of the Rectum as a Radiation-Induced Second Malignancy after Cervical Cancer Treatment: Case Report with Review of the Literature
Table 1
Pooled data of all identified case reports of radiation-induced leiomyosarcoma of the rectum after pelvic radiation therapy for cervical cancer.
| Authors | Year of publication | Patient’s age at diagnosis | Overall irradiation dosage (Gy) | Radiation modality | Time to diagnosis of a secondary malignancy (years) | Selected treatment strategy |
| Drumea et al. [11] | 1993 | 62 | 70 | 40 Gy EBRT1+30 Gy BT2 | 17 | Intra-abdominal resection of the rectum | Caporale et al. [12] | 2003 | N/A | N/A | N/A | N/A | N/A | Basu et al. [13] | 2012 | 79 | N/A | N/A | 26 | Intra-abdominal resection of the rectum | Garcia-Ortega et al. [14] | 2018 | 58 | 85 | 50 Gy EBRT+35 Gy BT | 8 | Sigmostomy+chemotherapy+pelvic exenteration+vulvectomy | Jayakumar et al. [15] | 2015 | 58 | N/A | N/A | 15 | Local excision | Current case report | 2019 | 62 | 100.5 | 70 Gy EBRT+30.5 Gy BT | 32 | ТМЕ+CME/CVL |
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1EBRT: external beam radiation therapy. 2BT: brachytherapy.
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