Primary CNS Lymphoma Arising from the 4^th Ventricle: A Case Report and Review of the Literature

Table 1

Summary of findings in individuals with 4^th ventricular central nervous system lymphoma, including age, sex, immune status at presentation, initial symptoms, lymphoma subtype, treatment, and survival [7–22].

Author, year	Age/sex	Immune status	Symptoms	Lymphoma subtype	Treatment	Survival
Werneck et al., 1977 [7]	17/F	IC	Meningeal signs	PCNSL	Unknown	Postmortem diagnosis
Haegelen et al., 2001 [8]	33/F	IC	Headache, vertigo, and ataxia	High-grade BCL	Resection, chemoradiation, ITC, and aSCT	No recurrence at 7 months
Hill et al., 2009 [9]	69/M	IC	Vomiting, nausea, anorexia, and weight loss	DLBCL	Chemotherapy, ITC	No recurrence at 3 months
Brar et al., 2012 [10] α	65/F	IC	Headache, nausea, and vomiting	High-grade BCL	Chemotherapy, ITC	No recurrence at 2 months
Bokhari et al., 2013 [11]	50/M	IC	Vomiting, nausea, headache, and confusion	DLBCL	Resection, chemoradiation, and ITC	No recurrence at 18 months
Rao et al., 2013 [12]	59/M	IC	Vomiting, nausea, vertigo, tremors of upper limbs and hands, and ataxia	DLBCL	Resection, chemotherapy	No recurrence at 8 months
Liao et al., 2014 [13]	77/M	IC	Vertigo, nausea, vomiting, and ataxia	DLBCL	Resection	No recurrence at 9 months
Fabiano et al., 2014 [14]	60/F	IC	Diplopia	DLBCL	Resection, chemoradiation, and ITC	No recurrence at 6 months
Grossman et al., 2014 [15]	66/M	IC	Ataxia, diplopia	PCNSL	Resection, unknown if further therapy	Unknown
Alabdulsalam et al., 2014 [16]	18/M	IC	Ataxia, cranial nerves IV, VII, IX, and X palsies	Burkitt	Resection, chemotherapy, and ITC	No recurrence at 18 months
Hsu et al., 2015 [17]	61/M	IC	Headache, dizziness, and ataxia	DLBCL	Resection, chemotherapy	No recurrence at 3 months
Suri et al., 2015 [18] β	15/M	IC	Headache, nausea, vomiting, and generalized tonic clonic seizure	DLBCL	Unknown	Unknown
Zhu et al., 2015 [19] ¥	66/M	IC	Headache, dizziness, diplopia, and cranial nerve VI, VII palsy	DLBCL	Chemotherapy	No recurrence at 6 months
Cellina et al., 2015 [20] €	65/M	IC	Weight loss, headache, diplopia, and ataxia	DLBCL	Chemotherapy	No recurrence at 2 weeks
Liu et al., 2016 [21]	6/M	IC	Headache	Burkitt	Unknown	Unknown
Yi et al., 2017 [22]	61/M	IC	Headache, confusion, ataxia, and urinary incontinence	DLBCL	Resection, chemoradiation	No recurrence at 20 months
Current case ψ	65/M	IC	Diplopia, vertigo, nausea, vomiting, weight loss, ataxia, and simple partial seizures	DLBCL	Chemoradiation, ITC	No recurrence at 8 months

: lymphoma in the 4^th ventricle and meninges. α: lymphoma in the 4^th ventricle and right lateral ventricle. β: lymphoma in the 4^th ventricle and bilateral ventricles. ¥: lymphoma in the 4^th ventricle and right lateral ventricle. €: lymphoma in the 4^th ventricle and hypothalamus. Ψ: lymphoma in the 4^th ventricle and pituitary gland. F: female; M: male; IC: immunocompetent; DLBCL: diffuse large B-cell lymphoma; BCL: B-cell lymphoma; ITC: intrathecal chemotherapy; aSCT: autologous stem cell transplant.