Case Reports in Oncological Medicine / 2019 / Article / Tab 1

Case Report

Primary CNS Lymphoma Arising from the 4th Ventricle: A Case Report and Review of the Literature

Table 1

Summary of findings in individuals with 4th ventricular central nervous system lymphoma, including age, sex, immune status at presentation, initial symptoms, lymphoma subtype, treatment, and survival [722].

Author, yearAge/sexImmune statusSymptomsLymphoma subtypeTreatmentSurvival

Werneck et al., 1977 [7]17/FICMeningeal signsPCNSLUnknownPostmortem diagnosis
Haegelen et al., 2001 [8]33/FICHeadache, vertigo, and ataxiaHigh-grade BCLResection, chemoradiation, ITC, and aSCTNo recurrence at 7 months
Hill et al., 2009 [9]69/MICVomiting, nausea, anorexia, and weight lossDLBCLChemotherapy, ITCNo recurrence at 3 months
Brar et al., 2012 [10] α65/FICHeadache, nausea, and vomitingHigh-grade BCLChemotherapy, ITCNo recurrence at 2 months
Bokhari et al., 2013 [11]50/MICVomiting, nausea, headache, and confusionDLBCLResection, chemoradiation, and ITCNo recurrence at 18 months
Rao et al., 2013 [12]59/MICVomiting, nausea, vertigo, tremors of upper limbs and hands, and ataxiaDLBCLResection, chemotherapyNo recurrence at 8 months
Liao et al., 2014 [13]77/MICVertigo, nausea, vomiting, and ataxiaDLBCLResectionNo recurrence at 9 months
Fabiano et al., 2014 [14]60/FICDiplopiaDLBCLResection, chemoradiation, and ITCNo recurrence at 6 months
Grossman et al., 2014 [15]66/MICAtaxia, diplopiaPCNSLResection, unknown if further therapyUnknown
Alabdulsalam et al., 2014 [16]18/MICAtaxia, cranial nerves IV, VII, IX, and X palsiesBurkittResection, chemotherapy, and ITCNo recurrence at 18 months
Hsu et al., 2015 [17]61/MICHeadache, dizziness, and ataxiaDLBCLResection, chemotherapyNo recurrence at 3 months
Suri et al., 2015 [18] β15/MICHeadache, nausea, vomiting, and generalized tonic clonic seizureDLBCLUnknownUnknown
Zhu et al., 2015 [19] ¥66/MICHeadache, dizziness, diplopia, and cranial nerve VI, VII palsyDLBCLChemotherapyNo recurrence at 6 months
Cellina et al., 2015 [20] €65/MICWeight loss, headache, diplopia, and ataxiaDLBCLChemotherapyNo recurrence at 2 weeks
Liu et al., 2016 [21]6/MICHeadacheBurkittUnknownUnknown
Yi et al., 2017 [22]61/MICHeadache, confusion, ataxia, and urinary incontinenceDLBCLResection, chemoradiationNo recurrence at 20 months
Current case ψ65/MICDiplopia, vertigo, nausea, vomiting, weight loss, ataxia, and simple partial seizuresDLBCLChemoradiation, ITCNo recurrence at 8 months

: lymphoma in the 4th ventricle and meninges. α: lymphoma in the 4th ventricle and right lateral ventricle. β: lymphoma in the 4th ventricle and bilateral ventricles. ¥: lymphoma in the 4th ventricle and right lateral ventricle. €: lymphoma in the 4th ventricle and hypothalamus. Ψ: lymphoma in the 4th ventricle and pituitary gland. F: female; M: male; IC: immunocompetent; DLBCL: diffuse large B-cell lymphoma; BCL: B-cell lymphoma; ITC: intrathecal chemotherapy; aSCT: autologous stem cell transplant.

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