Acute Immune-Mediated Thrombocytopenia due to Oxaliplatin and Irinotecan Therapy

Table 1

Known cases of oxaliplatin and irinotecan drug-induced immune-mediated thrombocytopenia. IVIG = intravenous immunoglobulin.

Study	Drug	Cycles prior to DITP	Platelet count (per μL)		Time to platelet recovery (days)	Treatment
			Initial	Nadir
Akdeniz et al. [17]	Oxaliplatin	12	151,000	20,000	6	Corticosteroids, platelets, IVIG
Bautista et al. [6]	Oxaliplatin	3	226,000	4,000	12	Antihistamine, corticosteroids, platelets
	Oxaliplatin	3	87,000	66,000	14	Corticosteroids
Buti et al. [18]	Oxaliplatin	11	117,000	17,000	NA	NA
Cobo et al. [19]	Oxaliplatin	12	202,000	7,000	NA	NA
Curtis et al. [8]	Oxaliplatin	17	150,000	6,000	7	Platelets
	Oxaliplatin	10	136,000	6,000	21	Observation
Curtis et al. [10]	Oxaliplatin, irinotecan	20	130,000	0	NA	Corticosteroids
	Oxaliplatin, irinotecan, leucovorin, dexamethasone, diphenhydramine, palonosetron	18	157,000	5,000	NA	Platelets
Earle et al. [20]	Oxaliplatin	1	99,000	6,000	14	Platelets, corticosteroids
Fontão-Wendel et al. [9]	Oxaliplatin	7	164,000	5,000	3	Corticosteroids, IVIG
James et al. [14]	Oxaliplatin	28	145,000	0	5	Corticosteroids, platelets
Koutras et al. [21]	Oxaliplatin	14	NA	NA	2	Corticosteroids, antihistamines, platelets
Mirtsching et al. [11]	Irinotecan	NA	347,000	84-100,000	NA	Observation
Mittal et al. [12]	Oxaliplatin	8	175,000	4,000	9	Platelets, corticosteroids
Ohta et al. [22]	Oxaliplatin	12	136,000	35,000	7	Corticosteroids
Pavic et al. [23]	Oxaliplatin	1	253,000	5,000	NA	Corticosteroids
Saif et al. [24]	Oxaliplatin	11	89,000	17,000	2	Platelets
Santodirocco et al. [25]	Oxaliplatin	15	124,000	21,000	5	Corticosteroids, platelets
Schade et al. [26]	Oxaliplatin	14	89,000	5,000	45	Platelets
Shao et al. [27]	Oxaliplatin	24	163,000	4,000	NA	Platelets
Suh et al. [15]	Oxaliplatin	11	113,000	3,000	60	Platelets, IVIG, corticosteroids
Suzuki et al. [28]	Oxaliplatin	23	253,000	3,000	5	Platelets, corticosteroids
Taleghani et al. [29]	Oxaliplatin	15	221,000	5,000	5	Platelets, corticosteroids
Tam et al. [this report]	Oxaliplatin, irinotecan	14	102,000	8,000	5	Corticosteroids, platelets
Curtis et al. [30]	Leucovorin, palonosetron	19	144	17	4	Dexamethasone
Pan et al. [31]	Oxaliplatin	28	NA	<5,000	4	IVIG, dexamethasone