Isolated Testicular Metastasis Diagnosed More than a Decade and a Half Post Primary Treatment for Prostate Cancer

Figure 3

(a) Gross image of bilateral simple orchiectomy specimens revealing sectioned left testicle with multiple intraparenchymal hard nodules (arrow), ranging from 0.2 to 2.5 cm in the greatest dimension, having a tan-white hard cut surface. (b) (Hematoxylin and Eosin stain, 4x magnification) Metastatic prostate adenocarcinoma infiltrating the testicular interstitium and sparing seminiferous tubules (top right). Lymphovascular invasion in tunica albuginea (bottom left). (c) (10x magnification) Prostate-specific antigen (PSA)-positive immune-histochemical stain, highlighting the infiltration of the left testicle with metastatic prostate adenocarcinoma. The tumor is mostly made of small monolayered back-to-back acini (Gleason pattern 3). Fewer foci with cribriform glands (Gleason pattern 4) are noted. This corresponds to Gleason score (grade group 2 of 5).

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