Case Report

A Case of Essential Thrombocythemia and IgA Nephropathy with Literature Review of the Concurrence

Table 1

Biopsy results of essential thrombocythemia and glomerulonephropathy cases.

CaseSexAgeRenal biopsy findingsRenal diagnosisTime after ET diagnosisSource

1Male68Mesangial PAS (+) fibrillary deposits without mesangial proliferation or crescent formation
(+) IgG on immunohistochemical staining
Weakly (+) IgA, IgM, and C3
Fibrillary glomerulonephritis30 yearsAsaba et al. [6]
2Male25Diffuse mesangial sclerosis with proliferation
Segmental capillary thickening immunohistochemical staining (-)
FSGSUnknownAu et al. [7]
3Female39Global & segmental sclerosis
Segmental mesangial IgM and C3 deposits
FSGSUnknownAu et al. [7]
4Female70Mesangial proliferation
Foot process effacement on electron microscopy
Mesangial deposits (-) for immunoglobulin or complement
N/A24 yearsUsui et al. [8]
5Female74Glomerular sclerosis
Diffuse mesangial proliferation
Features of chronic thrombotic microangiopathy
Glomerular basement membrane thickening
Myeloproliferative neoplasm-related glomerulopathy7 yearsSaid et al. [11]
6Female63Mesangial proliferation
IgM (+) on immunohistochemical staining
Weakly IgA (+) on immunohistochemical staining
Without mesangial deposits on electron microscopy
N/A3 yearsFujita and Hatta [13]
7Female76Mesangial proliferation with crescent formation
IgG and IgA (+) on immunohistochemical staining
Dense deposits in the mesangium on electron microscopy
IgA nephropathy3 yearsFujita and Hatta [13]
8Male76Segmental sclerosis and hyalinosis
Segmental IgM (+) deposits
Foot process effacement on electron microscopy
FSGS0 (same time diagnoses)Haraguchi et al. [14]
9Male75Glomerular sclerosis
Glomerular basement membrane thickening with mesangial proliferation
FSGS4 yearsSaigusa et al. [15]
10Male59Mesangial hypercellularity
Membrane thickening with mesangial proliferation
IgG and IgA (+) on immunohistochemical staining
Foot podocyte effacement and subendothelial on electron microscopy
IgA nephropathy2 monthsRahimian (2019)