Malignant Glioma in the Cerebellum Presenting as Multiple Small Lesions

Figure 2

Photomicrographs displaying pathognomonic histopathological features of malignant glioma. (a) H&E staining showed tumor cells with eosinophilic cytoplasm and pleomorphism characterized by dense proliferation and diffuse infiltration in the granular cell layer. (b) Nuclear pleomorphism and mitotic figures were observed, but no microvascular proliferation and micronecrosis were detected. (c) Immunohistochemical staining showed positivity for GFAP. (d) The majority of the tumor cells are positive for p53. (e) P53 staining also revealed infiltrating tumor cells in the granular layer of the cerebellum away from the area of dense tumor cells. (f) The MIB-1 labeling index was 21.3%.

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