Docetaxel-Induced Stevens-Johnson Syndrome in a Patient with Metastatic Prostate Adenocarcinoma

Figure 2

Biopsy images and pathology report. Microscopic examination of the skin (hematoxylin and eosin stain) was performed. The punch biopsies from the edges of both lesions (left forearm and left medial foot) show similar morphologic features. There is a predominantly normal intact stratum corneum overlying the epidermis. Within the dermis, there is interface dermatitis with a superficial perivascular infiltrate of lymphocytes with occasional neutrophils (a). Additionally, basal vacuolization with dyskeratotic keratinocytes scattered throughout all levels of the epidermis is seen. Mild interstitial and periadnexal lymphocytic inflammation are noted (b) as well as a focal area of neutrophils present in the keratin plug of a hair follicle (c). There is a focal area of incipient epidermal detachment present (d). No fungal elements or eosinophilic infiltration are noted in the specimens. The histologic features are consistent with toxic epidermal necrolysis/Stevens-Johnson syndrome.

(a)

(b)

(c)

(d)