Small-Cell Type, Poorly Differentiated Neuroendocrine Carcinoma of the Gallbladder: A Case Report and Review of the Literature

Figure 2

(a) Neuroendocrine carcinoma, small-cell type, comprised of tumor cells arranged in an organoid pattern with peripheral palisading. There is cell compression with molding and increased mitosis. H&E: magnification ×400. (b) Neuroendocrine carcinoma, small-cell type; the tumor cells are immunoreactive to immunomarker synaptophysin. Immunohistochemical stain: ×400. (c) Neuroendocrine carcinoma, small-cell type. Proliferating marker Ki-67 shows more than 90% intranuclear positivity. Immunohistochemical stain: ×400.

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