Successful Modified Therapy in a Patient with Probable Infection-Associated Hemophagocytic Lymphohistiocytosis

Table 1

Diagnostic criteria for HLH.

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Splenomegaly

Peripheral blood cytopenia, with at least two of the following:

  ( for )

and/or

Hemophagocytosis in bone marrow, spleen, lymph node, or liver

Low or absent NK cell activity

Elevated soluble CD-25 (soluble IL-2 receptor alpha) two standard deviations above age-adjusted laboratory-specific norms (or >2400 U/mL often cited in the literature)

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≥5/8 criteria must be met for the diagnosis. Adapted from Jordan et al. [3]