Successful Modified Therapy in a Patient with Probable Infection-Associated Hemophagocytic Lymphohistiocytosis

Table 3

Overview of patient with HLH associated with severe sepsis and septic shock.

Features consistent with severe sepsis and septic shock
Systemic inflammatory response syndrome	+
Infection	Unidentifiable
Hypotension requiring vasopressors	+
Acute respiratory distress syndrome requiring mechanical ventilation	−
Acute renal failure requiring dialysis	+
Altered mental status	+
	+ (4.1 mmol/L)
	+ ()
Disseminated intravascular coagulation	−
Other clinical and laboratory features
Anasarca	−
Hepatomegaly	−
Peak AST (IU/L)	174
Peak ALT (IU/L)	192
Peak LDH (IU/L)	285
Peak total bilirubin (mg/dL)	22.3
Peak direct bilirubin (mg/dL)	18.4
Peak prothrombin time (s)	26.6
Nadir hemoglobin (g/dL)	5.7 (on hospital day 20)
Nadir absolute neutrophil count (cells/mm^3)	1,600 (on hospital day 26)
Other features	Pericardial effusion, pneumonia, acalculus cholecystitis, acute cholangitis, abdominal wall abscess secondary to cholecystostomy tube