Malignant Phyllodes Tumor in an Adolescent Female: A Rare Case Report and Review of the Literature

Table 1

Literature review of malignant phyllodes tumors in adolescent females (part 1).

Case number	Age (years)	Delay (months)	Size (cm)	Treatment	Evolution	Result	Histology	Author
1	16	Short		Tumorectomy	2 recurrences at 12 months, 18 months, subcutaneous mastectomy+reconstruction	GH at 48 months	NS	Adami et al.
2	14	1.5	7 NS	Tumorectomy	—	GH at 48 months	NS	Azzopardi
3	15	?	NS	Tumorectomy, radiotherapy	2 pregnancies and 2 normal deliveries	GH at 66 months	NS	Rissanen and Holsti
4	17	14	9 right	Mastectomy	—	GH at 35 months	Lipomyxosarcoma	Mollitt et al.
5	16	0.5	7.5 NS	Tumorectomy	2 recurrences at 5 months, 9 months	GH at 37 months	Clear outlines with repression, mitoses 51/10 HPF, atypical aspect 3+, stroma fibrolipochondro sarcoma	Pietruszka and Barnes
6	17	NS	2.5-5 right	Tumorectomy	Adenofibroma at 8 months, tumorectomy	GH at 30 months	NS	Contarini et al.
7	12	6	13 NS	Mastectomy	—	GH at 204 months	NS	Briggs et al. (case 1)
8	18	2	1.5 NS	Tumorectomy	—	GH at 60 months	NS	Briggs et al. (case 2)
9	14	3	6 NS	Tumorectomy	—	Death cause? At 24 months	NS	Briggs et al. (case 3)
10	13	+3.5/2 months	5 NS	Tumorectomy	—	GH at 19 months	Stroma lipofibroma sarcoma	Grigioni et al. (case I)
11	18	+15/2 months	15 NS	Radical mastectomy	Recurrence at 3 months, pulmonary metastasis at 9 months	Death at 10 months	Very aggressive	Grigioni et al. (case 2)
12	18	84	left, nipple discharge	Tumorectomy	2 recurrences at 2 months, 6 months	GH at 42 months	NS	Naryshkin and Redfield
13	12	NS	right, no menarche	Radical mastectomy	—	GH at 12 months	Negative ganglia	Gibbs et al.
14	17	NS	30 axillary adenopathy	Radical mastectomy	—	GH at 96 months	Ganglionic invasion	Long et al.
15	14	4	10 right	Subcutaneous mastectomy and axillary clearing out	Multirecurrences as soon as 1 month, pulmonary and ovarian metastases, radical mastectomy, metastasectomy and exeresis of recurrences, chemotherapy mono then polychemotherapy, cobaltherapy, surgical castration	Death at 14 months	Inflammatory reactive axillary ganglia	Hoover et al.
16	18	12	right, orange peel	Tumorectomy	3 recurrences at 4 months, 8 months, 19 months tumorectomy then radical mastectomy with radiotherapy, pulmonary metastases at 19 months	Death at 19 months	Almost sarcomatous tumour	Kenda
17	14	4	10 suspect left homolateral axiallty adenopathy	Subcutaneous mastectomy and axillary image radiotherapy, polychemotherapy	Metastases at 2 months (liver, bones, and lungs)	Death at 2 months	Necrosis and haemorrhage, normal epithelium, fibrosarcoma, >10 mitoses/10 HPF, periductular stromal hyper development, 8 reactive ganglia, 2 ganglia, purely stromal metastases	Ogun et al.
18	15	1 NS	Painful mass in left breast	Subcutaneous mastectomy	—	Death at 22 months	NS	Turalba et al.
19	15	4		Enlarged tumorectomy, axillary clearing followed by mastectomy	—	GH at 100 months	Consistent with typical malignant pathology	Levique et al.
20	18	10	, right	Lumpectomy with wide local excision followed by simple mastectomy	Recurrence at 1.5 months following lumpectomy and 2 months following mastectomy	Death months following brain metastasis	Spindle cells with slight nuclear variation	Tiwari et al.
21	17	0.25	, right	Lumpectomy	—	GH at 2 month	Consistent with typical malignant pathology	Makar et al.

GH: good health; NS: not stated. Table adopted with permissions and additionas from Levêque et al. [14].