|
| S. NO | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 |
| Age/gender | 15
F | 7
M | 31
F | 45
F | 53
F | 63
M | 62
F | 62
M | 39
F | 24
M | 30
M | 30
M | 25
M | 62
M |
| Symptoms | Cough, sob, lethargy, satiety, anorexia | Respiratory distress | Dry cough, dyspnea | Dry cough | Productive cough and dyspnea | Progressive dyspnea and cough | Progressive dyspnea, weight loss, and rash. | Worsening dyspnea | Dyspnea, dry cough. | Dry cough, night sweats, dyspnea hemoptysis | Dry cough, night sweats, dyspnea on exertion, weight loss | Cough, sob, fever, and chest pain. | Cough, dyspnea on exertion | Dyspnea, dry cough fever for six weeks |
| Chest CT | Thickened interlobular septa | Mediastinal lymphadenopathy, B/l interstitial infiltrates | Mediastinal lymphadenopathy. Thickened interlobular septa, ground-glass opacities | Interlobular septal thickening, scattered GGO, nodularity along fissures, | Interstitial thickening, crazy paving, mediastinal lymphadenopathy | Enlarged med LN, diffuse reticular thickening, reticular-nodular pattern. | Diffuse reticulonodular and ground-glass opacities, pleural effusions | Subpleural reticulations pulmonary nodules, enlarged mediastinal LN | Interstitial and ground-glass opacities. Borderline mediastinal lymphadenopathy | Ground glass opacities, diffusely thickened interlobular septa, mediastinal and hilar LN enlarged | Thickening of peribronchovascular, interstitial, and interlobular septa. Ground glass opacities | Mediastinal lymphadenopathy and reticulonodular interstitial pattern. | Diffuse interstitial prominence | Bilateral interstitial infiltrates |
| Diagnostics | Open lung biopsy | Open lung biopsy | Transbronchial biopsy | Open lung biopsy | Bronchoalveolar lavage | Transbronchial biopsy | Bronchoalveolar lavage negative, cervical skin biopsy positive | Bronchoalveolar lavage and transbronchial biopsy | VATS surgical biopsy | Bronchoalveolar lavage. Central bronchoscopic biopsies. Gastric origin by EGD. | Bronchoalveolar lavage showed atypical cells. Transbronchial biopsies could not be done. | Bronchoscopy could not be completed. Diagnosed by surgical lung biopsy | Open lung biopsy | Transbronchial biopsy, prostate biopsy |
| Diagnosis | Adenocarcinoma unknown primary | Renal adenocarcinoma | Adenocarcinoma of colon | Signet ring gastric adenocarcinoma | Melanoma | Signet ring gastric adenocarcinoma | Signet ring gastric adenocarcinoma | Pulmonary adenocarcinoma | Gastric adenocarcinoma | Gastric adenocarcinoma with focal signet ring. | Signet ring cell gastric adenocarcinoma on EGD biopsy | Pulmonary adenocarcinoma | Pulmonary adenocarcinoma | Prostate adenocarcinoma |
| Symptom onset to diagnosis (days) | 107 | NA | 180 | 117 | Over 30 days | 150 | 180 | NA | NA | 60 | 60 | NA | 379 | 42 |
| Symptom to death (days) | 108 | NA | 191 | 119 | NA | 159 | 180 | NA | NA | NA | NA | NA | 382 | NA |
| Presentation to death (days) | 70 | NA | 16 | 29 | NA | NA | 67 | NA | NA | NA | NA | NA | 17 | NA |
| Diagnosis to death (days) | 1 | NA | 11 | 12 | NA | 7 | 7 | NA | NA | NA | NA | NA | 3 | NA |
| Therapy prior to diagnosis | Prednisone, clarithromycin, salbutamol, antitubercular, antipneumocystis therapy. | NA | Steroids for sarcoidosis. Folfox after diagnosis | Ciprofloxacin and erythromycin for bronchitis, right heart Cath, sildenafil, and ambrisentan for Pulm HTN. | Vancomycin and piperacillin-tazobactam | Antibiotics and steroids | Immunosuppressive therapy | NA | Steroids | Broad-spectrum antibiotics for 14 days, high dose steroids | Piperacillin-tazobactam, ciprofloxacin, and oseltamivir | NA | Antibiotics. | Not applicable. Survived. |
| Setting of diagnosis | ICU vent | NA | Post biopsy, ICU, vent | ICU. Biopsy while intubated, palliative postdiagnosis | Non-ICU setting | ICU on vent support | NA | Not in ICU | NA | NA | Na | NA | ICU | NA |
| Metastasis | Not available (NA) | NA | Thoracic and lumbar spine | Abdominal wall, tibia, femur, right humerus, lumbar spine | NA | NA | Skin | Contralateral pulmonary and spinal metastasis. | NA | Lung, pleura, right ribs, right iliac bone | NA | NA | NA | NA |
| Author | Gilchrist et al., Eur Resp Review [5] | Vanclaire et al., Arch Fr Pediatrics [6] | Thomas and Lenox, CMAJ [7] | Khachekian et al., J Am Osteopath Assoc. [8] | Biswas et al., Am Journal of Medicine [9] | Dikis et al., Clinics in Surgery [10] | Wang et al., Poster, chest meeting [11] | Guler et al. [12], Journal of clinical respiratory disease & care. | Gleason et al., J of clinical and diagnostic research [13] | Moubax et al., BMC research notes [14] | Meltem et al., Turkish thoracic journal [15] | Blanco et al., An Med Interna [16] | Mapel et al.,
Lung Cancer [17] | Cohen et al. [18],
Respiration |
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