Pituitary Metastatic Composite Tumors: A Case Report with Next-Generation Sequencing and Review of the Literature

Table 1

Literature review of clinical cases involving metastasis of systemic malignancy into a pituitary adenoma.

Cancer		Age	Gender	Pituitary tumor	Presentation	Radiation?	Post-op survival
Lung cancer	Sogani et al. 2014 [6]	64	M	Nonfunctioning	Vision loss	Yes	Not reported
	Hoellig et al. 2009 [7]	71	M	Nonfunctioning	Vision loss	No	13 days
	Rotondo et al. 2013 [8]	66	M	Prolactin	Headache	No	No surgery
	Molinatti et al. 1985 [9]	71	M	LH/FSH	Vision loss	Yes	1 month
	Post et al. 1988 [10]	77	M	Nonfunctioning	Vision loss	Yes	6 months
	Kovacs, 1973 [11]	N/A	N/A	N/A	N/A	N/A	N/A
	Scheithauer, 1984 [12]	N/A	N/A	N/A	N/A	N/A	N/A
	Hanna et al. 1999 [13]	42	F	Prolactin	Headache	Not reported	Not reported
	Nasr et al. 2006 [14]	44	F	Growth hormone	Vision loss/acromegaly	Yes	>3 months
	Fujimori et al. 2014 [15]	80	M	Not reported	Vision loss/CN 3 palsies	Yes	Not reported
Renal cancer	James et al. 1984 [16]	75	M	Nonfunctioning	Vision loss	Yes	Not reported
	Koutourousiou et al. 2010 [17]	42	F	ACTH	Cushing’s syndrome	Not reported	>55 months
	Koutourousiou et al. 2010 [17]	76	M	Nonfunctioning	Panhypopituitarism	Not reported	>27 months
	Weber et al. 2003 [18]	62	F	Nonfunctioning	Vision loss	Not reported	8 months
	Burns et al. 1973 [19]	78	M	Nonfunctioning	Fever	Not reported	No surgery
	Magnoli et al. 2014 [20]	76	F	FSH/LH	Vision loss, CN 3 palsies	No	24 months
Breast cancer	Bret et al. 2001 [21]	75	F	FSH/LH	Vision loss	No	>18 months
	Richardson and Katayama, 1971 [22]	70	F	Nonfunctioning	Headache/L hemiparesis	Yes	4 months
	van der Zwan et al. 1971 [23]	73	F	Nonfunctioning	Vision loss	No	1 month
	Zager et al. 1987 [24]	56	F	Nonfunctioning	CN 6 palsies	Yes	No surgery
	Mills et al. 2018 [25]	65	F	FSH/LH	Apoplexy	No	12 days
Idiopathic	Nassiri et al. 2012 [26]	55	F	Growth hormone	Acromegaly	Yes	5 months
	Bret et al. 2001 [21]	87	F	FSH/LH	Vision loss	No	>6 months
	Hurley et al. 1992 [27]	76	M	Growth hormone	Vision loss/acromegaly	No	6 months
	Post et al. 1988 [10]	61	F	ACTH	Vision loss	Yes	Not reported
Colon	Noga et al. 2001 [28]	60	M	Nonfunctioning	Vision loss	No	“Shortly”
	Skulsampaopol et al. 2017 [29]	53	M	Nonfunctioning	Vision loss	Yes	3 months
	Thewjitcharoen et al. 2014 [30]	65	M	Prolactin	Vision loss	No	9 months
Stomach	Van Seters et al. 1985 [31]	66	F	Prolactin	Vision loss	No	12 days
	Molinatti et al. 1985 [9]	66	F	Prolactin/growth hormone	Vision loss	No	2 days
Prostate	Ramsay et al. 1988 [32]	57	M	Nonfunctioning	Incidental	Yes	No surgery
Pancreas	Ramsay et al. 1988 [32]	50	F	ACTH	Cushing’s syndrome	Yes	No surgery
Mediastinum	Abe et al. 1997 [33]	46	F	Prolactin	Vision loss	No	6 months
Melanoma	Yang et al. 2017 [34]	62	F	Prolactin	Vision loss	No	>22 months