Neoadjuvant Radiation with Concurrent 5-FU Resulting in Complete Pathologic Response in Stage IIIB Squamous Cell Carcinoma of the Urethra

Figure 1

(a) Transurethral resection of tumor before the neoadjuvant chemoradiation therapy (2017). Low magnification shows urethra (1) and moderately differentiated invasive squamous cell carcinoma infiltrating in to the corpus spongiosum (2) (hematoxylin-eosin, original magnification ×4). (b) Status post neoadjuvant chemoradiation (2018). Transverse section of the penile shaft in the area of urethral stenosis. Low magnification shows stenotic urethra with extensive fibrosis and obliteration of corpus spongiosum (1) and extensive fibrosis of corpora cavernosum (2) (A). Note the absence of invasive carcinoma. The inset shows a high power view of the area of urethral stenosis (1) (B). (Hematoxy-lin-eosin, original magnification ×4 (A) and ×8 (B)).

(a)

(b)