Case Report

Management of Low-Grade Appendiceal Mucinous Neoplasm with Extensive Peritoneal Spread Diagnosed during Pregnancy: Two Case Reports and Literature Review

Table 2

Literature review of appendiceal tumors diagnosed during cesarean section.

#Author (year)AgePathologyPCGestational age at dxClinical findings during pregnancyHIPEC referralC-section surgeryC-section indicationStagingPostpartum treatmentPCICC scoreComplicationsBreast-feedingStatusChild

1Present case #231LAMNYes40 weeksUneventfulYesAppyPremature rapture of membranesCT chest/abd/pelv 3 weeks after C-sectionCRS/HIPEC (Mit-C) in 3 months27CC-0Prolonged ileus3 mos6 yrs, NEDHealthy
2Manan et al. (2010)[36]41Well-differentiated mucinous cystadenocarcinomaYesAt termUneventfulYesAppy, removal of all gelatinous materialLarge size of previous babies with complicated deliveryPostpartum tumor markersUnknown (referred to outside facility for CRS/HIPEC)--None--Healthy
3Abdu et al. (2009) [37]36Well-differentiated mucinous adenocarcinomaYes40 weeksLower abdominal pain at 37 weeksYesR hemicolectomyFailure of cervical dilation-Unknown (referred to outside facility for CRS/HIPEC)-----Healthy

4Inubashiri et al. (2019) [38]24LAMNNo38 weeksUneventfulNAAppyCephalopelvic disproportionCT scan 1 month after C-sectionNoneNANANone-6 daysHealthy
5Yohannes et al. (2019) [39]31LAMNNo38 weeksUneventfulNAAppyFetal hypoxia, dysfunctional 2nd stage of laborCT abd/pelv after C-sectionNoneNANA--LTFUHealthy
6Gallo et al. (2001) [40]29Well-differentiated mucinous cystadenocarcinomaNo38 weeksUneventfulNAAppyDysfunctional spontaneous deliveryPostpartum barium enema, abdominal scan, chest X-rayR hemicolectomyNANA--5 yrs, NEDHealthy
7Berrios (1965) [33]21Carcinoid tumorNoAt termUneventfulNAAppyCephalopelvic disproportion--NANA---Healthy
8Berrios et al. (1965) [33]30Carcinoid tumorNo38 weeks-NAAppy---NANA--No FU-
9Gökaslan et al. (2001) [41]30Carcinoid tumorNo--NAAppy-NoneNoneNANA--5 mos, NEDHealthy

The cases reporting peritoneal spread at presentation are in italics. Abd: abdomen; Appy: appendectomy; CC: completeness of cytoreduction; CRS/HIPEC: cytoreductive surgery with hyperthermic intraperitoneal chemotherapy; C-section: cesarean section; CT: computed tomography; Dx: diagnosis; FU: follow-up; LAMN: low-grade appendiceal mucinous neoplasm; LTFU: lost to follow-up; Mit-C: mitomycin C; mos: months; NA: not applicable; NED: no evidence of disease; PC: peritoneal carcinomatosis; PCI: peritoneal cancer index; Pelv: pelvis; Yrs: years.