Posterior Reversible Encephalopathy Syndrome (PRES) and Drug-Induced Hypersensitivity Syndrome (DIHS) following Immunotherapy and BRAF/MEK Inhibition with Continued Response in Metastatic Melanoma

Figure 4

(a) A low-power view showing mild upper dermal perivascular and perifollicular inflammation (H&E 40 magnification), (b) basketweave cornified layer and a upper dermal perivascular and interstitial inflammatory infiltrate (H&E 100 magnification), (c) closer view of the perivascular and interstitial inflammatory infiltrate without significant interface or epidermal abnormality (H&E 200 magnification), (d) closer view of the perifollicular inflammation (H&E 200 magnification), (e) closer view of the dermal inflammatory infiltrate of mostly small lymphocytes and a few eosinophils, consistent with drug reaction (H&E 400 magnification), and (f) high-power view of the dermal inflammatory infiltrate of lymphocytes and a few eosinophils (H&E 600 magnification).

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