A Case of Retroperitoneal Synovial Sarcoma in Pregnancy Treated with Antepartum Doxorubicin plus Ifosfamide Chemotherapy

Figure 2

Histology of synovial sarcoma case. Diagnostic biopsy (a) demonstrated proliferation of spindle to epithelioid cells of monomorphic appearance with elongated nuclei and scant cytoplasm arranged in a whorled “herringbone” architecture (Hematoxylin and Eosin, 100x). Fli-1 immunohistochemistry (b) demonstrated strong, diffuse nuclear staining, confirming the diagnosis (200x). The posttreatment resection specimen demonstrated substantial treatment effected with the majority of residual tumor mass now comprised of areas of histiocytic infiltration (c) fibrosis, pigment deposition, and chronic inflammation (d) (Hematoxylin and Eosin, 20x).

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