A Rare Case of Pure Primary Large Cell Neuroendocrine Carcinoma of the Gallbladder

Figure 2

Representative H&E sections of the gallbladder LCNEC and some of the immunostains performed. Very low-power H&E view (20x) of the LCNEC showing necrosis and tumor cells (a), low-power H&E section (40x) showing the trabecular growth pattern (b), and a middle-power view (200x) showing the neuroendocrine features of the LCNEC (c). Sections (d–h) show the CD56, AE1/AE3, c-kit, neuron-specific enolase, and Ki-67 immunostains, respectively.

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