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Case Reports in Ophthalmological Medicine
Volume 2014, Article ID 452462, 3 pages
Case Report

Tolerance to Systemic Isotretinoin Therapy in Two Patients Using Highly Wettable Contact Lenses

1Ophthalmology Clinic, Ankara Atatürk Training and Research Hospital, 06800 Ankara, Turkey
2Dermatology Clinic, Ankara Atatürk Training and Research Hospital, 06800 Ankara, Turkey

Received 20 September 2013; Accepted 10 December 2013; Published 28 January 2014

Academic Editors: H. Eguchi and M. B. Parodi

Copyright © 2014 Ayşegül Arman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. Numerous ocular side effects have been reported with the use of systemic isotretinoin therapy. Herein, we presented two contact lens user patients who did not have contact lens intolerance during systemic isotretinoin therapy. Methods. 25-year-old male and 20-year-old female patients with severe acne vulgaris who were using highly wettable silicone hydrogel contact lenses which increase tear film stability were examined. Tear film function tests including Schirmer tests and tear break up time (TBUT) test and ocular surface staining with fluorescein were done. Subjective ocular complaints were scored with ocular surface disease index (OSDI) questionnaire. Patients were followed up monthly and examinations were repeated at each visit. Results. Both patients completed the therapy after a cumulative dose of 140 mg/kg isotretinoin in 6 months. The OSDI score and tear film function tests before and after treatment were all within normal limits. Discussion. Highly wettable contact lenses that provide increase in the tear film stability may be used during systemic retinoid therapy under close followups. Although isotretinoin affects ocular glands, the differences between tolerances to this retinoid therapy need to be investigated in larger patient groups using contact lenses.