Case Report

Benign Lymphoid Hyperplasia Presenting as Bilateral Scleral Nodules

Table 1

Immunohistochemistry analysis.

MarkerResultDescription

CD3 (PS1)T cells positivePan T cell, epsilon subunit of the CD3 T cell receptor complex
CD5 (4C7)T cells positivePan T cell antigen, mature B cell subset, and thymic carcinoma
CD10NegativeFollicle center B cells, CALLA (B and T ALL)
CD20B cells positivePan B cell antigen (L26)
CD21Follicular dendritic cells positiveC3d and EBV receptor, mature B cells, and follicular dendritic cells
CD23 (MHM6)B cells positiveLow affinity IgE receptor, mature B cells, and CLL/SLL
CD43T cells positiveT cells, B cell subset, myeloid cells, and histiocytes (Leu22)
CD68Histiocytes/macrophages positiveMacrophages and myeloid cells (KP1)
PAX-5 (BSAP)B cells positiveB cell and Hodgkin’s lymphoma
BCL-1NegativeMantle cell lymphoma (Cyclin D1, PRAD-1)
BCL-2 IHCLymphocytes positiveAntiapoptosis protein, follicular lymphoma, and B cell subset
BCL-6NegativeFollicle center B cells
MUM-1Plasma cells positivePlasma cells postgerminal center B cells, activated T cells
Kappa (Px)Polytypic in plasma cellsKappa immunoglobulin light chain, B cells, and plasma cells
Lambda (Px)Polytypic in plasma cellsLambda immunoglobulin light chain, B cells, and plasma cells
Ki-67 (MIB-1)1–4%Cell proliferation marker (MIB-1)