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Case Reports in Ophthalmological Medicine
Volume 2015 (2015), Article ID 439409, 3 pages
Case Report

Nystagmus in Laurence-Moon-Biedl Syndrome

1Center for Neurology in Fairfax, VA, USA
2King Faisal Specialist Hospital, UOH, P.O. Box 6252, Hail 81442, Saudi Arabia
3King Khaled Hospital, Hail, Saudi Arabia

Received 15 October 2014; Revised 18 February 2015; Accepted 25 February 2015

Academic Editor: Toshihide Kurihara

Copyright © 2015 A. Bruce Janati et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. Laurence-Moon-Biedl (LMB) syndrome is a rare autosomal-recessive ciliopathy with manifold symptomatology. The cardinal clinical features include retinitis pigmentosa, obesity, intellectual delay, polydactyly/syndactyly, and hypogenitalism. In this paper, the authors report on three siblings with Laurence-Moon-Biedl syndrome associated with a probable pseudocycloid form of congenital nystagmus. Methods. This was a case study conducted at King Khaled Hospital. Results. The authors assert that the nystagmus in Laurence-Moon-Biedl syndrome is essentially similar to idiopathic motor-defect nystagmus and the nystagmus seen in optic nerve hypoplasia, ocular albinism, and bilateral opacities of the ocular media. Conclusion. The data support the previous hypothesis that there is a common brain stem motor abnormality in sensory-defect and motor-defect nystagmus.