IgG4-Related Disease Presenting as Isolated Scleritis

Figure 2

Histological Findings. (a) Hematoxylin-eosin stain at low-power field showing a marked lymphocytic plasmatic infiltrate. (b) Immunohistochemistry study for IgG. (c) Immunohistochemistry study for CD4. (d) Immunohistochemistry study of the same area demonstrating a diffuse pattern of IgG4-positive cells: a high proportion of the plasma cells are positive for IgG4 (~40%). (e) Immunohistochemistry study for CD4 cells at high-power field. (f) Immunohistochemistry study at high-power field showing >30 IgG4-positive cells per field.

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