Case Report
Bilateral Iris Mammillations in Amblyopic Eyes without Oculodermal Melanocytosis or Neurofibromatosis
Table 1
Modified table from Ragge et al. (1996) summarizing the case reports of iris mammillations [
1].
| No | Age/sex | Ethnic origin | Ocular involvement | Iris involvement | Melanosis oculi | Naevus | Ocular disease | Other disease | Journal | Year | Author |
| 1 | 8F | Caucasian | U | P | N | Y | Myopia | None | Eye | 1996 | Ragge |
| 2 | 8F | Hispanic | B | T | N | N | High myopia | CHD, cleft palate, marfanoid habitus | Eye | 1996 | Ragge |
| 3 | 9M | Hispanic | U | P | Y | Y | Esotropia and amblyopia of other eye | Seizures | Eye | 1996 | Ragge |
| 4 | 20M | Asian-Indian | B | P | Y | N | Iris hamartomas | Neurofibromatosis type 1 | Eye | 1996 | Ragge |
| 5 | 7F | Hispanic | B | ST | N | N | Optic neuritis | TB frontal arachnoid cyst | Eye | 1996 | Ragge |
| 6 | 10F | Middle Eastern | B | T | Y | N | Calcified ciliary body mass | Mother also had bilateral iris elevations | Eye | 1996 | Ragge |
| 7 | 5F | Hispanic | B | T | Y | N | Congenital glaucoma | Phakomatosis pigmentovascularis Iib | Eye | 1996 | Ragge |
| 8 | 28M | Asian (Indian) | B | ST | N | N | None | None | Eye | 1996 | Ragge |
| 9 | 2M | N. African | B | T | Y | N | None | Ectopic Mongolian spot, preauricular skin tag, abnormal rib | Eye | 1996 | Ragge |
| 10 | 8F | - | U | T | Y | N | Choroidal melanoma, Retinal detachment | None | Arch Ophthalmol | 2000 | Gündüz |
| 11 | 1M | Caucasian | B | - | N | N | None | None | J Fr Ophtalmol | 2006 | Kharrat |
| 12 | 8M | Caucasian | B | - | N | N | None | None | J Fr Ophtalmol | 2006 | Kharrat |
| 13 | 5M | Caucasian | U | - | Y | N | Ipsilateral ocular melanocytosis | None | J Fr Ophtalmol | 2006 | Kharrat |
| 14 | 9F | Türkler | B | P | N | N | Optic nerve damage, Persistent pupillary membrane | None | Clin Exp Optom | 2007 | Ozdamar |
| 15 | 7F | Asian (Malaysian) | B | T | N | N | None | Siblings, CAH, Clitoris acne, Labioscrotal hyperpigmentation | BMJ Case Reports | 2010 | Peyman |
| 16 | 7F | Asian (Malaysian) | B | T | N | N | None | Siblings, CAH, Clitoris acne, Labioscrotal hyperpigmentation | BMJ Case Reports | 2010 | Peyman |
| 17 | 5M | Caucasian | U | T | Y | N | Scleral pigmentation | None | Arch Soc Esp Oftalmol | 2014 | Marugán B |
| 18 | 8F | Hispanic | B | T | N | N | None | None | Arch Soc Esp Oftalmol | 2014 | Marugán B |
| 19 | 16F | Caucasian | B | T | N | N | None | None | Arch Soc Esp Oftalmol | 2014 | Marugán B |
| 20 | 22F | Hispanic | B | P | Y | N | Eyelid trichilemmoma | Twins, Cowden syndrome | JAAD Case Reports | 2016 | Suaiti |
| 21 | 22F | Hispanic | B | P | Y | N | Eyelid trichilemmoma | Twins, Cowden syndrome | JAAD Case Reports | 2016 | Suaiti |
| 22 | 12M | Hispanic | B | ST | Y | Y | Monolateral ocular melanocytosis, Glaucoma, Choroidal haemangioma | Sturge-Weber Syndrome, naevus flammeus of the face | Csse Rep Ophthalmol | 2017 | Plateroti |
| 23 | 10F | Asian, (Japanese) | B | T | N | N | Amblyopia | None | Case Rep Ophthalmol Med | This Case | Yamamoto, Mimura |
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Age, years; M, male; F, female; U, unilateral; B, bilateral; P, partial; T, total; ST, subtotal; Y, yes; N, no; CHD, congenital heart disease; CAH, congenital adrenal hyperplasia.
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