(a)-(b) Colour fundus photography showed arteriolar attenuation, peripapillary atrophy, optic disc pallor, macular hemorrhage and typical retinal pigment deposits (bone spicules) involving the mid-peripheral retina (c) Indocyanine green angiography (ICGA) revealed a well-distinct “triangular shape” area of intense hypercyanescence (“hot spot”) corresponding to the neovascularization (d) B-Scan optical coherence tomography angiography revealed high-flow intraretinal neovascularization originated in the superficial layer descending into a tuft-shaped lesion toward the sub-RPE space. (e)–(h) Optical Coherence Tomography Angiography images (6 × 6 mm) revealing the progression of the tuft-shaped lesion from the superficial layer to choroid capillary. (e) Superficial capillary plexus segmentation. (f) Deep capillary plexus segmentation. (g) Outer retinal layer segmentation. (h) Choriocapillaris segmentation. (i)–(j) Spectral Domain-Optical Coherence Tomography at baseline. (k)–(l) Spectral Domain-Optical Coherence Tomography after treatment.