Tubulointerstitial Nephritis and Uveitis Syndrome: Case Series and Literature Review

Table 1

Description of the presented cases.

	Case 1	Case 2	Case 3	Case 4
Sex	Female	Female	Female	Male
Age (years)	49	54	32	16
Clinical presentation	Lumbar pain, dark urine, asthenia, anorexia, weight loss, leg and periorbital edema, unilateral anterior uveitis	Urinary frequency, asthenia, anorexia, weight loss, unilateral anterior and intermediate uveitis	Bilateral anterior and intermediate uveitis, asthenia, arthralgia, and myalgia	Bilateral panuveitis, fever, myalgias, anorexia, and weight loss
First ocular symptoms			+	+
First renal symptoms	+	+
Clinical diagnosis			+	+
Histological diagnosis	+	+
Ocular treatment	Topical corticosteroid, mydriatic	Topical corticosteroid, mydriatic	Topical corticosteroid, mydriatic	Topical corticosteroid, mydriatic
Systemic treatment	Oral prednisolone (1 mg/kg/day) with progressive withdrawal, azathioprine (2 mg/kg/day)	Oral prednisolone (1 mg/kg/day) with progressive withdrawal	Oral prednisolone (1 mg/kg/day) with progressive withdrawal, azathioprine (2 mg/kg/day)	Oral prednisolone (1 mg/kg/day) with progressive withdrawal, methotrexate (25 mg/week)
Follow-up	Uveitis recurrence: once	Uveitis recurrence: once	Uveitis recurrence: twice	No recurrence