Acute Hydrops with Total Corneal Edema in a Very Young Child with Keratoconus: The Youngest Age Reported Case

Table 1

Summary of several studies reporting corneal hydrops in children with KCN.

Study	Country	Age (years)/sex	Association
Rehany and Rumelt (1995) [13]	Israel	5/male	Bilateral advanced keratoconus, previous treatment for vernal conjunctivitis, and epithelial and stromal edema on the temporal side of the right cornea
Rahman and Anwar (2006) [17]	United Kingdom	6/female	Severe keratoconus
Rehany and Rumelt (1995) [13]	Israel	7/male	Advanced keratoconus with central stromal edema in the left eye with negative history of eye and systemic disorders and no history of habitual rubbing of the eye
Panahi-Bazaz et al. (2014) [18]	Iran	7/female	Bilateral corneal hydrops associated with eye rubbing secondary vernal keratoconjunctivitis (VKC)
Ioannidis et al. (2005) [19]	United Kingdom	7/female	Hydrops secondary to a chronic persistent eye-rubbing with no systemic involvement
Downie (2014) [20]	Australia	8/female	Bilateral acute corneal hydrops associated with severe atopy and no previous eye examination
Slim et al. (2015) [21]	Lebanon	10/male	Hydrops in an advanced KCN
Ozcan and Ersoz (2007) [22]	Turkey	11/male	Down syndrome and vigorous eye rubbing
Rehany and Rumelt (1995) [13]	Israel	11/male	Acute hydrops in the left eye in a bilateral advanced keratoconus, history of vernal conjunctivitis
Bilgin et al. (2013) [23]	Turkey	12/male	Simultaneous bilateral acute hydrops in Leber congenital amaurosis (LCA)
Khan et al. (2006) [24]	Saudi Arabia	16/male	Hydrops in a KCN patient with cornea plana
Current Study (2021)	Iran	5/female	Acute corneal hydrops associated with total limbus to limbus corneal edema, use of AS-OCT to enhance understanding of the structural corneal changes