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Case Reports in Orthopedics
Volume 2013, Article ID 850502, 5 pages
http://dx.doi.org/10.1155/2013/850502
Case Report

Subchondral Bone Regenerative Effect of Two Different Biomaterials in the Same Patient

1I Clinic, Rizzoli Orthopaedic Institute, Bologna University, Via Giulio Cesare Pupilli 1, 40136 Bologna, Italy
2Orthopaedics and Traumatology, I Clinic, Rizzoli Orthopaedic Institute, Bologna University, Via Giulio Cesare Pupilli 1, 40136 Bologna, Italy

Received 2 May 2013; Accepted 17 June 2013

Academic Editors: E. R. Ahlmann, M. Cadossi, and A. Sakamoto

Copyright © 2013 Marco Cavallo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This case report aims at highlighting the different effects on subchondral bone regeneration of two different biomaterials in the same patient, in addition to bone marrow derived cell transplantation (BMDCT) in ankle. A 15-year-old boy underwent a first BMDCT on a hyaluronate membrane to treat a deep osteochondral lesion (8 mm). The procedure failed: subchondral bone was still present at MRI. Two years after the first operation, the same procedure was performed on a collagen membrane with DBM filling the defect. After one year, AOFAS score was 100 points, and MRI showed a complete filling of the defect. The T2 mapping MRI after one year showed chondral tissue with values in the range of hyaline cartilage. In this case, DBM and the collagen membrane were demonstrated to be good biomaterials to restore subchondral bone: this is a critical step towards the regeneration of a healthy hyaline cartilage.