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Case Reports in Orthopedics
Volume 2014, Article ID 597207, 6 pages
Case Report

Fourth Primary Malignant Tumor in a Patient with Possible Li-Fraumeni Syndrome: Synchronous Diagnosis of Postirradiation Sarcoma, Cutaneous Relapse of a Previous Soft Tissue Sarcoma, and Lung Adenocarcinoma

1Orthopaedics and Traumatology, Memorial Sisli Hospital, Piyalepasa Bulv., Sisli, 34385 Istanbul, Turkey
2Orthopaedics and Traumatology, Istanbul University School of Medicine, Turgut Özal Millet Caddesi, Çapa Tip Fakültesi, Fatih, 34098 Istanbul, Turkey

Received 10 July 2014; Accepted 31 October 2014; Published 18 November 2014

Academic Editor: Sungtaek Jung

Copyright © 2014 Feridun Yumrukçal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We present a 46-year-old female patient who is diagnosed with synchronous postirradiation sarcoma, cutaneous relapse of a previous soft tissue sarcoma, and lung adenocarcinoma. More than one malignant tumor at the same time with an accompanying relapse of a previous malignant tumor is a rare entity. A relatively young patient diagnosed with adenocarcinoma of the urethra before age 40, which is an unusual tumor for that age, later three more different malignant tumors being diagnosed, two of which are synchronous, causes the suspicion of Li-Fraumeni syndrome.