Cutaneous Basal Cell Carcinoma with Bone Metastases: An Orthopaedic Case Report

Figure 2

Microscopic findings of the right shoulder mass (a-e) and right iliac crest metastasis (f). (a) Low power image shows ulcerated BCC adjacent to normal skin. The tumor consists of large nodules and irregular angulated nests of tumor cells with peripheral palisading and surrounding myxoid stroma infiltrating into the deep dermis (hematoxylin-eosin, original magnification 40x). (b) Some areas of the BCC show histologic pattern of nodular subtype (hematoxylin-eosin, original magnification 100x). (c) Other areas of BCC show histologic pattern of morpheaform subtype (hematoxylin-eosin, original magnification 100x). (d) Foci of perineural invasion by BCC in the deep dermis (hematoxylin-eosin, original magnification 100x). (e) Foci of lymphovascular invasion by BCC (hematoxylin-eosin, original magnification 200x). (f) The right iliac crest biopsy shows metastatic BCC wrapping around bone trabeculae with morphological features similar to the right shoulder mass (hematoxylin-eosin, original magnification 200x).