Osteosarcomatous Transformation in the Setting of Mazabraud’s Syndrome: A Case Report and Review of the Literature

Table 1

Published studies of sarcomatous transformation of fibrous dysplasia in the setting of Mazabraud’s Syndrome specifically (McCune-Albright studies are excluded).

Case	Author	Year	Title	Patient age	Gender	Diagnosis	Location	Presenting symptom
1	Roze, R. et al.	1967	Fibrous dysplasia of bone and myxomas of the soft tissues. Localized sarcomatous degeneration [French]	72	Female	Osteosarcoma	Right tibia (distal)	Pain
2	Witkin, G. et al.	1986	Osteogenic sarcoma and soft tissue myxoma in a patient with fibrous dysplasia and hemoglobins	41	Male	Osteosarcoma	Left tibia	Asymptomatic
3	Nyguen, B. et al.	2005	Mazabraud’s Syndrome with sarcomatous transformation: scintigraphic and radiologic imaging	48	Male	Spindle cell sarcoma	Right humerus (proximal)	Pain
4	Crawford, E. et al.	2009	Osteosarcoma of the proximal part of the radius in Mazabraud syndrome. A case report	63	Male	Osteosarcoma	Right radius (proximal)	Pain
5	Szymanski, C. et al.	2015	Chondrosarcoma of the femur in Mazabraud’s syndrome: a first case study	51	Female	Chondrosarcoma	Left femur	Pain and swelling
6	Calleja, M. et al.	2018	Mutational analysis of high-grade spindle cell sarcoma of the femur in Mazabraud’s syndrome	36	Female	Spindle cell sarcoma	Right femur	Pain
7	Ghert, M. et al.	2018	Osteosarcomatous transformation in the setting of Mazabraud’s Syndrome: a case report and review of the literature	62	Female	Osteosarcoma	Right femur (proximal)	Pain