Case Series
Continuous Local Antibiotics Perfusion Therapy for Acute Deep Infections after Open Fractures
Table 2
Summary of management and clinical results.
| Patient number | Duration of CLAP (days) | Surgical intervention | Systemic antibiotics | CRP (mg/dL) Pre | CRP (mg/dL) Post† | Outcomes | Follow-up (months) | Recurrence | Bone union |
| 1 | 12 | Debridement | TAZ/PIPC, 15 days | 4.20 | 2.84 | No | Yes | 45 | 2 | 10 | Debridement | MINO, 10 days | 0.57 | 0.12 | No | Yes | 45 | 3 | 8 | Debridement | CEZ, 11 days | 0.64 | 0.13 | No | Yes | 46 | 4 | 7 | Debridement | SBT/ABPC, 8 days | 1.96 | 0.76 | No | Yes | 20 | 5 | 9 | Debridement | CEZ, 29 days | 8.40 | 0.44 | No | Yes | 18 | 6 | 11 | Debridement | SBT/ABPC, 21 days | 5.46 | 4.22 | No | Yes | 43 | Average | 9.5 | | | 3.54 | 1.42 | | | 36 |
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CLAP: continuous local antibiotic perfusion; CRP: C-reactive protein; TAZ/PIPC: tazobactam/piperacillin; MINO: minocycline; CEZ: cefazolin; SBT/ABPC: sulbactam/ampicillin; “Pre” indicates immediately before starting CLAP therapy. †“Post” indicates within two days after finishing CLAP therapy. |