Complementary Effects of Surgery and Pexidartinib in the Management of Patients with Complex Diffuse-Tenosynovial Giant Cell Tumor

Figure 11

Histology images in the knee post-pexidartinib treatment. Hypercellular region of the popliteal tumor after pexidartinib treatment is indistinguishable from that seen in the original biopsy (a). This photomicrograph displays areas of highly mitotic proliferative tumor (19 mitoses per 10 high power fields) that were widely seen in the viable tumor (b). Approximately, 30% of the mass was composed of these areas of fibrotic hypocellular tissue with low proliferative rates (c).

(a)

(b)

(c)