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Case Reports in Otolaryngology
Volume 2012, Article ID 139310, 6 pages
Case Report

A Case of Radiation-Induced Multifocal Laryngeal Angiosarcoma Presenting as a Diagnostic Dilemma

1Division of Laryngology, Department of Otology and Laryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary Boston, MA 02114, USA
2Department of Radiation Oncology, Princess Margaret Hospital, Toronto, ON, M5G 2Mg, Canada
3Department of Radiation Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI 48201, USA
4Department of Otolaryngology-Head and Neck Surgery, Wayne State University and Karmanos Cancer Institute, Detroit, MI 48201, USA
5Department of Surgery, John D. Dingell VA Medical Center, Detroit, MI 48201, USA

Received 10 June 2012; Accepted 28 June 2012

Academic Editors: M.-K. Chen and W. Issing

Copyright © 2012 Jayme R. Dowdall et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Head and neck sarcomas are relatively rare tumors, with angiosarcomas representing a small subset. Angiosarcoma is a malignant endothelial neoplasm characterized by atypical, multilayered, or solid endothelial proliferation with vasoformative architecture. The global incidence of irradiation-associated sarcoma is estimated as between 0.03% and 0.08%. Here we reported the case of an elderly woman previously treated with radiation more than 20 years ago for an unknown primary of head and neck. This interesting case presented as a diagnostic challenge, and multiple biopsies were required to eventually establish the diagnosis of laryngeal angiosarcoma. We additionally have confirmation from our prior radiation records that the patient did, in fact, receive a substantial dose of radiation to the site previously. To our knowledge, this case represents the first report of a documented radiation-induced multifocal laryngeal angiosarcoma.