Case Report
A Case of Radiation-Induced Multifocal Laryngeal Angiosarcoma Presenting as a Diagnostic Dilemma
Table 1
Cases that fulfill diagnostic criteria for radiation-induced angiosarcoma of the larynx.
| Author | Initial primary | RT | Latency | Pre-op biopsy | Final pathology | Recurrence/multifocality | Survival |
| Thomas 1979 [1] | Vocal cord SCCA | 70 Gy | 11 years | Dysplasia with dilation of capillaries and lymphatics, no infiltrative growth | Supraglottic Angiosarcoma | Yes, local recurrence, no multifocal lesions, had pharyngocutaneous fistula | 13 months s/p partial pharyngolaryngectomy, final pathology angiosarcoma |
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Miura et al. 2003 [2] | Supraglottis SCCA, cervical TB | 68.4 Gy; unknown 42 years | 10 years | Initial biopsy interpreted as SCCA | Supraglottic Angiosarcoma | Skin, breast and muscle | 3 years and six months after laryngectomy followed by excision and chemo for metastatic lesions |
| Current case | Unknown primary SCCA | 59.4 Gy | 20 years | Initial biopsy inconclusive × 3, 4th biopsy angiosarcoma | Supraglottic Angiosarcoma | Yes, 2 foci epiglottis and base of tongue, yeast recurrence | 2 years after narrow-field laryngectomy |
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