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Case Reports in Otolaryngology
Volume 2012, Article ID 316165, 4 pages
Case Report

Small Cell Carcinoma of the Larynx Treated by Concurrent Chemoradiotherapy: A Case Report

1Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
2Department of Otolaryngology, Suita Municipal Hospital, 2-13-20 Katayama, Suita, Osaka 564-0082, Japan

Received 29 December 2011; Accepted 1 February 2012

Academic Editors: J. I. De Diego, K. Morshed, and A. Rapoport

Copyright © 2012 Susumu Nakahara et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Small cell carcinoma (SmCC) generally occurs in the lung and extrapulmonary SmCC is a relatively rare entity. Here, we present a case of a 42-year-old male with SmCC of the larynx diagnosed as cT3N0M0. Concurrent chemoradiotherapy using cisplatin (CDDP) and etoposide (VP-16) was given, which achieved complete response (CR). Lung metastasis became evident in 16 months whereas the locoregional control remained good. In spite of intensive chemotherapy using CDDP and irinotecan (CPT-11), the patient died of disease in 34 months after the first interview. Since the prognosis of laryngeal SmCC is extremely poor, organ preservation therapy should be considered instead of radical laryngectomy.