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Case Reports in Otolaryngology
Volume 2012, Article ID 582180, 6 pages
Case Report

Low-Grade Esthesioneuroblastoma Presenting as SIADH: A Review of Atypical Manifestations

1Department of Otolaryngology, Walter Reed National Military Medical Center, 8901 Wisconsin Avenue Bethesda, MD 20889-5600, USA
2Department of Pathology, Tripler Army Medical Center, Honolulu, HI 96859 5000, USA
3Department of Otolaryngology, Tripler Army Medical Center, Tripler AMC, Honolulu, HI 96859 5000, USA
4Grove City College, Grove City, PA 16127, USA

Received 17 October 2012; Accepted 8 November 2012

Academic Editors: J. I. De Diego, M. T. Kalcioglu, K. Morshed, C.-S. Rhee, and G. Zhou

Copyright © 2012 Andrew Senchak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Esthesioneuroblastoma (ENB) is a neuroendocrine tumor that typically manifests as advanced stage malignancy in the superior nasal cavity. The hallmark symptoms include nasal obstruction and epistaxis, which result from local tissue invasion. Atypical clinical features can also arise and must be considered when diagnosing and treating ENB. These can include origin in an ectopic location, unusual presenting symptoms, and associated paraneoplastic syndromes. The case described here reports a nasal cavity ENB with atypical clinical features that occurred in a young female. Her tumor was low grade, appeared to arise primarily from the middle nasal cavity, and presented as syndrome of inappropriate antidiuretic hormone (SIADH). She also became pregnant shortly after diagnosis, which had implications on her surgical management. We review the atypical features that uncommonly occur with ENB and the clinical considerations that arise from these unusual characteristics.