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Case Reports in Otolaryngology
Volume 2013 (2013), Article ID 505636, 4 pages
http://dx.doi.org/10.1155/2013/505636
Case Report

Vertigo as the First Sign of Chronic Myeloid Leukemia: A Case Report and Literature Review

Otoneurology Unit, Department of Otorhinolaryngology and Head and Neck Pathology, University Hospital of Salamanca, Paseo San Vicente 58-182, 37007 Salamanca, Spain

Received 16 December 2012; Accepted 9 January 2013

Academic Editors: C. F. Hwang and A. Rapoport

Copyright © 2013 Rubén Martín-Hernández et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Acute vestibular deficit as the first sign of leukemia is extremely rare. The literature shows some cases of sudden hearing loss accompanied by instability and associated with hyperviscosity syndrome. We present the case of a patient who presents a harmonic vestibular deficit of the right ear. The complementary studies revealed an abnormally high level of leukocytes. A peripheral blood cytogenetic analysis is performed due to a high suspicion of leukemia, and the results show BCR/ABL fusion gene with a cut point in the M-BCR region, which confirms the diagnosis of chronic myeloid leukemia. In this case we detail the importance of taking hematological disorders into consideration in the differential diagnosis of patients with otoneurological symptoms, and we also review the etiopathogenic mechanisms, symptoms, diagnosis, and therapeutic options for chronic myeloid leukemia with sudden hearing loss and vertigo.