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Case Reports in Otolaryngology
Volume 2013, Article ID 579527, 4 pages
Case Report

Recombinant Human Thyrotropin-Aided Radioiodine Therapy in Tracheal Obstruction by an Invading Well-Differentiated Thyroid Carcinoma

1Department of Endocrinology-Diabetes, Panagia General Hospital, 22 Plastira Street, 55132 Thessaloniki, Greece
2Pulmonary Department, St. Luke's Hospital, 55236 Thessaloniki, Greece
3Department of Endocrinology, Hippokration Hospital of Thessaloniki, 54642 Thessaloniki, Greece
4Laboratory of Anatomy Department of Physical Education and Sports Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece
5Third Department of Nuclear Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece
6Department of Endocrine Surgery, St. Luke's Hospital, 55236 Thessaloniki, Greece
73rd Department of Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece

Received 8 January 2013; Accepted 4 February 2013

Academic Editors: H. Sudhoff and S. Ulualp

Copyright © 2013 Nickolaos Pontikides et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Papillary thyroid carcinomas (PTCs) usually extend to lymph nodes in the neck and mediastinum. Rarely, they invade the neighboring upper airway anatomical structures. We report a 56-year-old woman who presented with symptoms of upper airway obstruction. Imaging studies revealed a lesion derived from the thyroid which invaded and obstructed the trachea, which appeared to be a highly differentiated PTC. Total thyroidectomy was performed, with removal of the endotracheal part of the mass along with the corresponding anterior tracheal rings. Two months later, a whole body I131 scan after recombinant human thyroid-stimulating hormone (rh-TSH) administration was performed and revealed a residual mass in upper left thyroid lobe. Subsequently, 150 mCi I131 were given following rh-TSH administration. Nine months later, there was no sign of residual tumor. This case is the first one reported in the literature regarding rh-TSH administration prior to RAI ablation in a PTC obstructing the trachea.