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Case Reports in Otolaryngology
Volume 2013, Article ID 967536, 4 pages
Case Report

Solitary Polypoid Laryngeal Xanthoma

1Department of Pathology, La Fe University Hospital, School of Medicine and Dentistry, University of Valencia, Avenida Campanar 21, 46009 Valencia, Spain
2Department of Otolaryngology, La Fe University Hospital, Avenida Campanar 21, 46009 Valencia, Spain
3Department of Stomatology, School of Medicine and Dentistry, University of Valencia, Avenida Blasco Ibañez 17, 46010 Valencia, Spain

Received 31 March 2013; Accepted 6 May 2013

Academic Editors: C. F. Hwang, W. Issing, and K. Morshed

Copyright © 2013 Francisco Vera-Sempere et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We report the case of a 51-year-old male smoker with diabetes mellitus and hyperlipidaemia and a long history of human immunodeficiency virus (HIV)/hepatitis C virus (HCV) infection treated with various antiretroviral regimes, who was referred to the otolaryngology department with progressive dysphonia. Fibre-optic laryngoscopy showed a solitary, yellowish-white pedunculated polyp on the anterior third of the left cord, with no other abnormality. Pathological analysis revealed a polypoid laryngeal xanthoma that was immunoreactive against CD68, perilipin, and adipophilin. This unusual laryngeal lesion in the clinical context of our patient suggests a possible role of antiretroviral treatment in the pathogenesis of these xanthomas.