Solitary Polypoid Laryngeal Xanthoma

Figure 1

Panoramic histological view of the laryngeal polypoid lesion (1a) (H-E, 15x). Frequent islets of clear foam cells with congestive vessels are seen below a laryngeal squamous epithelium without atypia (1b) (H-E, 100x). At higher magnifications, the foam cells have a xanthomatous appearance (1c) (H-E, 250x) and are negative for PAS (1d) (PAS, 400x). Immunohistochemical staining shows intense cytoplasmic reactivity in the foam cells against CD68 (ie) (CD68, 250x) and adipophilin (1f) (adipophilin, 250x).

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