Endoscopic CO(2) Laser Horizontal Partial Laryngectomy in Larynx Carcinosarcoma
Definitive histological examination showing a carcinosarcoma with carcinomatous and sarcomatous components. Immunohistochemistry with monoclonal antibodies (anticytokeratin CK7, CK 8–18, and CK 5-6) for actin, P63, vimentin, S100, desmin, and EMA (epithelial membrane antigen) has been performed. The tumour showed strong positivity for vimentin, EMA, and focal elements for CK 8–18. (a) Hematoxylin-eosin (20x). “In situ” squamous cell carcinoma with cells infiltrating the subepithelial corium. Lower right: undifferentiated spindle cell carcinoma cells. (b) Hematoxylin-eosin (20x). “In situ” squamous cell carcinoma with atypical cells at the basal layers, a sarcomatous component, and hemosiderin deposits. (c) EMA (20x). Immunohistochemistry: carcinomatous cells with membrane positivity for EMA. (d) CK 8–18 (40x): focal positivity for cytokeratin 8–18.