Immunophenotype Heterogeneity in Nasal Glomangiopericytoma

Figure 1

(a)–(c) Histopathological section of the biopsy showing the tumor as located in the nasal mucosa ((a) asterisks for the tumor tissue, arrow for mucosa). (b) Focal collection of submucosal tumor cells (arrow). (c) Occasional whirling pattern of tumor cells (arrow). ((a)–(c) Hematoxylin and eosin stain.) (d)–(n) Tumor cells expressing CD31 (d) and CD34 (e), showing missing expression of D2-40 ((f) arrows for rare intratumor positive vessels), expressing nuclear Ki67 ((g) arrows), CD99 ((h) dot-like cytoplasmic expression in some tumor cells/arrow), CD146 ((i) asterisks for positive tumor cells), and Bcl2 ((j)-(k) asterisks in the positive zones, some of them at the periphery of negative whirling zones), as well as progesterone receptor ((l) asterisks), WT1 ((m) arrows), and expressing moderately and diffusely mTOR ((n) asterisks) and membrane and cytoplasmic EGFR ((o) arrows). Magnification ×25 ((a), (n)), ×50 ((b), (j)), ×200 (i), and ×400 ((c), (d), (e), (f), (g), (h), (k), (l), (m), (o)).

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