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Case Reports in Otolaryngology
Volume 2016, Article ID 1234196, 3 pages
Case Report

Primary Aspergillosis of the Larynx

Department of Otolaryngology, University at Buffalo School of Medicine and Biomedical Sciences (SUNY), 1237 Delaware Avenue, Buffalo, NY 14209, USA

Received 11 September 2015; Accepted 18 January 2016

Academic Editor: Kamal Morshed

Copyright © 2016 Richard H. Law and Samuel A. Reyes. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Laryngeal aspergillosis is most commonly seen as a result of secondary invasion from the lungs and tracheobronchial tree in immunocompromised hosts. Primary aspergillosis of the larynx is, however, rare with few cases documented over the past fifty years. We report a case of a 73-year-old woman who presented with persistent hoarseness. She is a nonsmoker with a history of asthma and chronic bronchiectasis treated with bronchodilators, inhaled and oral corticosteroids, and nebulized tobramycin. Direct laryngoscopy with vocal cord stripping confirmed the diagnosis of invasive aspergillosis with no manifestations elsewhere. The patient was successfully treated with oral voriconazole with no signs of recurrence. Although several major risk factors contributing to the development of primary aspergillosis of the larynx have been discussed in the literature, there has been no mention of inhaled antibiotics causing this rare presentation to the best of our knowledge. We, therefore, highlight the use of inhaled tobramycin as a unique catalyst leading to the rapid onset of this rare presentation.